The term 'AFFECTING THE WHOLE BODY' can be summarized by the word 'systemic', which means affecting the entire body. Systemic diseases are those that affect the entire body, rather than just one organ or area. Examples of systemic diseases include diabetes, lupus, and rheumatoid arthritis. These diseases can cause a wide range of symptoms, from fatigue to joint pain, and can have a significant impact on a person's quality of life.