The term '2's' can refer to a few different things. The first crossword solution is 'VEEPS, ' which stands for Vice Presidents. This is a title given to the second highest ranking officials in the United States government, who serve under the President. The second solution is 'RAIMI, ' which is the last name of Sam Raimi, an American film director, producer, actor, and screenwriter. He is best known for directing the Spider-Man trilogy and the Evil Dead series. The third solution is 'RUNNERSUP, ' which refers to those who come in second place in a competition or race.